Less than a month ago spammers started to send spam using PDF files. SARE reacted immediately providing PDFInfo ruleset for SpamAssassin. Thanks to them, ruleset was very effective. My current setup is almost spam free due to combining of several spam-fighting techniques. But I was getting so much of this PDF spam and was so happy to get rid of it with new SARE rules.
Now spammers adapted. They send attachments az pseudo-zip files (in fact, rar files), which are not caught by any filters. Fortunately I found that ClamAV can catch [almost] all this spam with SaneSecurity signatures.
I downloaded a script to check for and get new signatures, and now I am already started to catch this spam. Spammers are out of luck again...

polarizers 2 cents
[1] www.rulesemporium.com/plugins.htm
GREYLISTING is a system, currently employed by Yahoo, most notably, where the receiving mail server basically asks the sender to retry again in a few minutes.
Current spam strategies are using botnets to send out spam in batches, where 1 IP always tries to deliever several spam-emails under different sender names.
Due to the nature of spam, it is almost impossible for them to do retries, because they are probably sending out millions of emails daily, and if they retry, they usually do so within 5-20 seconds.
Setting the minimum greylisting interval to 2 or 3 will get rid of them all. The tradeoff is email delivery which is not real-time anymore, but IMHO it's more than worth it.